Highlighted Works:

Meanwell, M., et al. 'A Short de novo Synthesis of Nucleoside Analogs' Science, 2020

Davison, E., et al. 'Practical and Concise Synthesis of Nucleoside Analogs', Nat. Protoc., 2022

Fluorination aldol for rapid access of nucleoside analogues:

Nucleoside analogues are a rich source of anti-cancer and anti-viral therapeutics but unfortunately, methods to synthesize complex nucleoside analogues are arduous and lengthy. We recently demonstrated that utilizing an α-fluorination aldol reaction, we can access a wide array on nucleoside analogues with substitutions at different positions around the ribose ring, all in under 6 steps from the starting nucleobase. We are now looking to expand this methodology to include even more complex subtitutions, as well as carbanucleosides, thionucleosides and azanucleosides.