PUBLICATIONS

62. Christian Roth, Sherry Chan, Wendy Offen, Glyn Hemsworth, Lianne Willems, Dustin King, Dr. Vimal Varghese, Prof. Robert Britton, Prof. David Vocadlo, Prof. Gideon Davies ' Structural and Functional Insight into Human O-GlcNAcase' Nature Chemical Biology, 2017

61. Dr. Matthew Nodwell, Hua Yang, Milena Colovic, Dr. Zheliang Yuan, Helen Merkens, Dr. Martin Reiner, Francois Benard, Dr. Paul Schaffer, Prof. Robert Britton '18F-Fluorination of Unactivated C-H Bonds in Branched Aliphatic Amino Acids: Direct Synthesis of Oncological Positron Emission Tomography Imaging Agents'  Journal of the American Chemical Society, 2017, 139(10), 3595-3598

60. Dr. Stanley Chang, Dr. Michael Holmes, Dr. Jeffrey Mowat, Michael Meanwell, Prof. Robert Britton ' a-Arylation and Ring Expansion of Annulated Cyclobutanones: Stereoselective Synthesis of Functionalized Tetralones' Angewandte Chemie, International Edition. 2016, 56(3), 748-752

59. Christopher Adamson, Robert J. Pengelly, Saeideh Shamsi Kazem Abadi, Dr. Saswati Chakladar, Jason Draper, Prof. Robert Britton, Dr. Tracey M. Gloster, Prof. Andrew J. Bennet 'Structural Snapshots for Mechanism-Based Inactivation of a Glycoside Hydrolase by Cyclopropyl Carbasugars' Angewandte Chemie, International Edition 201655 (48), 14978-14982

          * Selected as a "Very Important Paper"


58. Rainer E. Martin, Johannes Lehmann, Thibault Alzieu, Mario Lenz, Marjorie A. Carnero Corrales, Johannes D. Aebi, Hans Peter Marki, Bernd Kuhn, Kurt Amrein, Alexander V. Mayweg, Robert Britton 'Synthesis of Annulated Pyridines as Inhibitors of Aldosterone Synthase (CYP11B2)' Organic and Biomolecular Chemistry 2016, 14, 5922-5927

          * Selected as a "Hot Article"


57. Michael Meanwell, Matthew B. Nodwell, Rainer E. Martin, Robert Britton 'A Convenient Late-Stage Fluorination of Pyridylic C−H Bonds with N-Fluorobenzenesulfonimide' Angewandte Chemie, International Edition, 2016, 55 (42), 13244-13248.


56. Huimin Zhai, Michael Hrabar, Regine Gries, Gerhard Gries,Robert Britton ' 'Total Synthesis, Stereochemical Assignment, and Field-Testing of the Sex Pheromone of the Strepsipteran Xenos peckii'.Chemistry: A European Journal, 2016, 22 (18), 6190-6193.

         *Selected for the Back Cover of Journal

55. Milan Bergeron-Brlek, Jake Goodwin-Tindall, Nevena Cekic, Christian Roth, Wesley F. Zandberg, Xiaoyang Shan, Vimal Varghese, Sherry Chan, Gideon J. Davies, David J. Vocadlo, Robert Britton 'A Convenient Approach to Stereoisomeric Iminocyclitols: Generation of Potent Brain-Permeable OGA Inhibitors' Angewandte Chemie, International Edition, 2015, 54 (51), 15429-15433.

54. Shira D. Halperin, Daniel Kwon, Michael Holmes, Erik L. Regalado, Louis-Charles Campeau, Daniel A. DiRocco, Robert Britton 'Development of a Direct Photocatalytic C-H Fluorination for the Preparative Synthesis of Odanacatib' Organic Letters, 2015, 17 (21), 5200-5203.


53. Stanley Chang, Soo Hur, Robert Britton 'Total Synthesis and Configurational Assignment of Ascospiroketal A'' Chemistry - A European Journal, 2015, 21 (46), 16646-16653.


52. Michael Hrabar, Huimin Zhai, Regine Gries, Paul W. Schaefer, Jason Draper, Robert Britton, Gerhard Gries '(7E,11E)-3,5,9,11-Tetramethyltridecadienal: Sex Pheromone of the Strepsipteran Xenos peckii' Journal of Chemical Ecology, 2015, 41 (8), 732-739.


51. Michael Holmes, Daniel Kwon, Matthew Taron, Robert Britton 'Total Synthesis of Amphirionin-4' Org Lett2015, 17 (15), 3868-3871.


50. Matthew B. Nodwell, Abhimanyu Bagai, Shira D. Halperin, Rainer E. Martin, Henner Knust, Robert Britton 'Direct photocatalytic fluorination of benzylic C-H bonds with N-fluorobenzenesulfonimide' Chemical Communications, 2015, 51, 11783-11786.


49. Milan Bergeron-Brlek, Michael Meanwell, Robert Britton 'Direct synthesis of imino-C-nucleoside analogues and other biologically active iminosugars' Nature Communications, 2015, 6, 6903.


48. Regine Gries, Robert Britton, Michael Holmes, Huimin Zhai, Jason Draper, Gerhard Gries 'Bed Bug Aggregation Pheromone Finally Identified' Angewandte Chemie, International Edition, 2015, 54, 1135-1138.


47. Stanley Chang, Soo Hur, Robert Britton 'Total Synthesis of Ascospiroketal A Through a Ag(I)-Promoted Cyclization Cascade' Angewandte Chemie, International Edition, 2015, 54, 211.


46. Shira D. Halperin, Hope Fan, Stanley Chang, Rainer E. Martin, Robert Britton 'A Convenient Photocatalytic Fluorination of Unactivated C-H Bonds' Angewandte Chemie, International Edition, 2014, 53, 4690-4693.

45. Thibaut Alzieu, Johannes Lehmann, Ajay B. Naidu, Rainer E. Martin, Robert Britton 'Converting Oxazoles Into Imidazoles: New Opportunities for Diversity-oriented Synthesis' Chemical Communications, 2014, 50, 1867-1870.


44. Zena Qadoumi, James Senior, Milan Bergeron-Brlek, Robert Britton 'Direct Access to Iminosugars through an Interrupted Kondrat'eva Reaction' Synlett, 2013, 24, 2427.


43. Michael T. Holmes, Robert Britton 'Total Synthesis and Structural Revision of Laurefurenynes A and B' Chemistry - A European Journal, 2013, 19, 12649.


42. Vijay Dhand, Stanley Chang, Robert Britton 'Total Synthesis of the Cytotoxic Anhydrophytosphingosine Pachastrissamine (Jaspine B)' Journal of Organic Chemistry, 2013, 78, 8208-8213.


41. Milan Bergeron-Brlek, Timothy Teoh, Robert Britton 'A Tandem Organocatalytic a-Chlorination-Aldol Reaction That Proceeds with Dynamic Kinetic Resolution: A Powerful Tool for Carbohydrate Synthesis' Organic Letters, 2013, 15, 3554-3557.

40. Johannes Lehmann, Thibaut Alzieu, Rainer E. Martin, Robert Britton 'The Kondrat'eva Reaction in Flow: Direct Access to Annulated Pyridines' Organic Letters, 2013, 15, 3550-3553.


39. Stanley Chang, Saheena Desai, Daniel B. Leznoff, Nabyl Merbouh, Robert Britton 'A Short, Gram-Scale Synthesis of 2,5-Disubstituted Furans' European Journal of Organic Chemistry, 2013, 3219-3222.


38. Vijay Dhand, Jason A. Draper, Jarod Moore, Robert Britton 'A Short, Organocatalytic Formal Synthesis of (-)-Swainsonine and Related Alkaloids' Organic Letters, 2013, 15, 1914-1917.


37. Shira Halperin, Robert Britton 'Chlorine, an atom economical auxiliary for asymmetric aldol reactions' Organic and Biomolecular Chemistry, 2013, 11, 1702-1705.


36. Jeffrey Mowat, James Senior, Baldip Kang, Robert Britton 'Scalable Synthesis of the Pink Gypsy Moth Lymantria mathura Sex Pheromone (-)-Mathuralure' Canadian Journal of Chemistry, 2013, 91, 235-239.

35. Robert Britton, Baldip Kang 'α-Haloaldehydes: versatile building blocks for natural product synthesis' Natural Product Reports, 2013, 30, 227-236.


34. Stanley Chang, Robert Britton 'Enantioselective Synthesis of Spiroacetals via Silver(I)-Promoted Alkylation of Hemiacetals: Total Synthesis of Cephalosporolides E and F' Organic Letters, 2012, 14, 5844-5847.


33. Johannes Lehmann, Mario Lenz, Robert Britton, Rainer E. Martin 'Synthesis of Annulated Pyridines from Oxazoles in Flow' Roche Letters (an internal, peer reviewed company publication), November, 2012.

32. Philipp Zerbe, Angela Chiang, Macaire Yuen, Björn Hamberger, Britta Hamberger, Jason A. Draper, Robert Britton, Jörg Bohlmann. 'Bifunctional cis-abienol synthase from Abies balsamea discovered by transcriptome sequencing and its implications for diterpenoid fragrance production.' Journal of Biological Chemistry, 2012 , 287, 12121-12131.

31. Inhee Cho, Labros Meimetis, Lee Belding , Michael J. Katz, Travis Dudding, Robert Britton 'Sequential Directed ortho Metalations of Hydrobenzoin: Rapid Access to Hydrobenzoin Analogues Useful for Asymmetric Synthesis' Beilstein Journal of Organic Chemistry, 2011, 7, 1315-1322.


30. Shira Halperin, Baldip Kang, Robert Britton 'Lithium Aldol Reactions of a -Chloroaldehydes Provide Versatile Building Bocks for Natural Product Synthesis' Synthesis, 2011, 12, 1946.


29. Jason Draper, Robert Britton 'A Concise and Stereoselective Synthesis of Hydroxypyrrolidines: Rapid Synthesis of Preussin' Organic Letters, 2010, 12, 4034-4037.


28. Francis Gosselin, Robert A. Britton, Ian W. Davies, Sarah J. Dolman, Danny Gauvreau, R. Scott Hoerrner, Gregory Hughes, Jacob Janey, Stephen Lau, Carmela Molinaro, Christian Nadeau, Paul D. O'Shea, Michael Palucki, Rick Sidler 'A Practical Synthesis of 5-Lipoxygenase Inhibitor MK-0633' Journal of Organic Chemistry, 2010, 75, 4154-4160.


27. Baldip Kang, Stanley Chang, Shannon Dekker, Robert Britton* 'Regioselective and Stereoselective Cyclizations of Chloropolyols in Water: Rapid Synthesis of Hydroxytetrahydrofurans' Organic Letters, 2010, 12, 1716-1719.


26. Inhee Cho, Labros Meimetis, Robert Britton* 'Bidirectional Metalation of Hydrobenzoin: Direct Access to New Chiral Ligands and Auxiliaries' Organic Letters , 2009, 11, 1903-1906.


25. Jeffrey Mowat, Baldip Kang, Brendan Fonovic, Travis Dudding*, Robert Britton* 'Inverse Temperature Dependence in the Diastereoselective Addition of Grignard Reagents to a Tetrahydrofurfural' Organic Letters , 2009, 11, 2057-2060.


24. Baldip Kang, Jeffrey Mowat, Thomas Pinter, Robert Britton 'Development of a Concise and General Enantioselective Approach to 2,5-Disubstituted-3-hydroxytetrahydrofurans.' Organic Letters, 2009 , 11, 1717-1720.


23. Jeffrey Mowat, Regine Gries, Gerhard Gries, Grigori Khaskin, Robert Britton. '(S)-2-Pentyl (R)-3-Hydroxyhexanoate, a Banana Volatile and Its Olfactory Recognition by the Common Fruit Fly, Drosophila melanogaster' Journal of Natural Products, 2009, 72 (4), 772-776.


22. Robert Britton, Grigori Khaskin, Gerhard Gries. 'A chromatography-free synthesis of (2S,12Z)-2-acetoxy-12-heptadecene - The major sex pheromone component of the pistachio twig borer moth (Kermania pistaciella)' Canadian Journal of Chemistry, 2009, 87(2), 430-432.


21. Baldip Kang, Robert Britton. 'A General Method for the Synthesis of Nonracemic trans-Epoxides: Concise Syntheses of trans-Epoxide-Containing Insect Sex Pheromones' Organic Letters, 2007, 9(24), 5083-5086.


20. Francis Gosselin, Robert Britton, Jeffery Mowat, Paul O'Shea, Ian Davies. 'Asymmetric Organozincate Additions to Ethyl 2,2,2-Trifluoropyruvate.' Synlett, 2007, 14, 2193.


19. Regine Gries, Grigori Khaskin, Hassan Daroogheh, Cafer Mart, Serpil Karadag, Mehmet Kubilay, Robert Britton, Gerhard Gries. '(2 S,12 Z)-2-acetoxy-12-heptadecene: Major sex pheromone component of pistachio twig borer, Kermania pistaciella' Journal of Chemical Ecology, 2006, 32, 2667.


Post-doctoral Publications

18. Ian Paterson, Robert Britton, Oscar Delgado, Nicola M. Gardner, Arndt Meyer, Guy J. Naylor, Karine G. Poullennec. 'Total Synthesis Of (-)-Dictyostatin, A Microtubule-Stabilising Anticancer Macrolide Of Marine Sponge Origin.' Tetrahedron, 2010, 66, 6534-6545.


17. Ian Paterson, Kate Ashton, Robert Britton, Guiseppe Cecere, Gaelle Chouraqui, Gordon J. Florence, Henner Knust, Jonathon Stafford. 'Total Synthesis of (-)-Reidispongiolide A: an Actin-Targeting Macrolide Isolated from the Marine Sponge Reidispongia coerulea.' Chemistry - An Asian Journal, 2008, 3, 367-387.

16. Ian Paterson, Kate Ashton, Robert Britton, Guiseppe Cecere, Gaelle Chouraqui, Gordon J. Florence, Jonathon Stafford. ' Total Synthesis of Reidispongiolide A, an Actin-Targeting Marine Macrolide.' Angewandte Chemie, International Edition, 2007, 46, 6167-6171.


15. Ian Paterson, Dirk Menche, Robert Britton, Anders E. Hakansson, Maria A. Silvia-Martinez; 'Conformational studies and solution structure of laulimalide and simplified analogues using NMR spectroscopy and molecular modelling.' Tetrahedron Letters, 2005, 46, 3677-3682.


14. Ian Paterson, Robert Britton, Oscar Delgado, Arndt Meyer, Karine G. Poullennec; 'Total Synthesis and Configurational Assignment of (-)-Dictyostatin, a Microtubule-Stabilizing Macrolide of Marine Sponge Origin.' Angewandte Chemie, International Edition, 2004, 43, 35, 4629-4633.

          Cover picture: Angewandte Chemie International Edition, 2004, 43, 4537. 

          This article was also featured in Chemical and Engineering News, July 12, 2004, 82, 28, 9. 


13. Ian Paterson, Robert Britton, Kate Ashton, Henner Knust, Jonathan Stafford 'Synthesis of antimicrofilament marine macrolides: synthesis and configurational assignment of a C5-C16 degradation fragment of reidispongiolide A.' Proceedings of the National Academy of Sciences, 2004, 101, 11986.


12. Ian Paterson, Robert Britton, Oscar Delgado, Amy E. Wright; 'Stereochemical determination of dictyostatin, a novel microtubule-stabilising macrolide from the marine sponge Corallistidae sp.' Chemical Communications, 2004, 632-633.

11. Ian Paterson, Kate Ashton, Robert Britton, Henner Knust 'Toward the Synthesis of Reidispongiolide A: Stereocontrolled Synthesis of the C 17-C 22 and C 23-C 35 Degradation Fragments.' Organic Letters, 2003, 5, 1963-1966.

Doctoral Publications

10. Robert Britton, Edward Piers, Brian O.Patrick; 'Total Synthesis of (±)-13-Methoxy-15-oxozoapatlin, a Rearranged Kaurane Diterpenoid.' Journal of Organic Chemistry, 2004, 69, 3068-3075.


9. Xiuxian Jiang, Baoguang Zhao, Robert Britton, Lynette Y. Lim, Dan Leong, Jasbinder S. Sanghera, Bin-Bing S. Zhou, Edward Piers, Raymond J. Andersen, Michel Roberge; 'Inhibition of Chk1 by the G2 DNA damage checkpoint inhibitor isogranulatimide.' Molecular Cancer Therapeutics, 2004, 3, 1221-1227.

8. Robert Britton, Michel Roberge, Colleen Brown, Rob van Soest, Raymond J. Andersen; 'New Okadaic Acid Analogues From the Marine Sponge Merriamum oxeato andtheir Effect on Mitosis.' Journal of Natural Products, 2003, 66, 838-843.

7. Robert Britton, E. Dilip de Silva, Christina M. Bigg, Lianne M. McHardy, Michel Roberge, Raymond J. Andersen; 'Synthetic Transformations of Eleutherobin Reveal New Features of Its Microtubule-Stabalizing Pharmacophore.' Journal of the American Chemical Society, 2001, 123, 8632-8633.


6. Robert Britton, Michel Roberge, Hans Berisch, Raymond J. Andersen; 'Antimitotic Diterpenoids from Erythropodium caribaeorum: isolation artifacts and putative biosynthetic intermediates.' Tetrahedron Letters, 2001, 42, 2953-2956.


5. Robert Britton, Jaine H. de Oliveira, Raymond J. Andersen, Roberto Berlinck; 'Granulatimide and 6-Bromogranulatimide: Minor Alkaloids of the Brazilian Ascidian Didemnum Granulatum.' Journal of Natural Products, 2001, 64, 254-255.

4. Edward Piers, Robert Britton, Raymond J. Andersen; 'Improved Synthesis of Isogranulatimide, a G2 Checkpoint Inhibitor. Synthesis of Didemnimide C, Isodidemnimide A, Neodidemnimide A, 17-Methylgranulatimide and Isogranulatimides A-C.' Journal of Organic Chemistry, 2000, 65, 530-535.

3. Roberto Berlinck, Robert Britton, Edward Piers, Raymond J. Andersen, Michel Roberge, Lynette Lim, Rosana Moreira da Rocha; 'Inibidores do Desenvolvimento Celular: Uma Nova Abordagem para o Tratamento de Tumores Sólidos.', Estudos Avançados, 1999, 13, 35, 207.


2. Roberto Berlinck, Robert Britton, Edward Piers, Lynette Lim, Michele Roberge, Rosana Moreira da Rocha, Raymond J. Andersen; 'Granulatimide and Isogranulatimide, Aromatic Alkaloids with G2 Checkpoint Inhibition Activity Isolated from the Brazilian Ascidian Didemnum Granulatum.' Journal of Organic Chemistry, 1998, 63, 9850-9856.


1. Michel Roberge, Roberto G. S. Berlinck, Lin Xu, Hilary J. Anderson, Lynette Y. Lim, Darko Curman, Cheri M. Stringer, Stephen H. Friend, Peter Davies, Inez Vincent, Stephen J. Haggarty, Michael T. Kelly, Robert Britton, Edward Piers, Raymond J. Andersen; 'High Throughput Assay for G2 Checkpoint Inhibitors and Identification of the Structurally Novel Compound Isogranulatimide.' Cancer Research, 1998, 58, 5701-5706.

Patents

4. R. Gries, G. Khaskin, H. Daroogeh, C. Mart, R. Britton, G. Gries; 'Composition of Chemicals for Manipulating the Behaviour of the Pistachio Twig Borer, Kermania Pistaciella (Lepidoptera: Oinophilidae)' PCT Patent Application No. PCT/CA2006/000059. Filed Jan. 6, 2006.

3. O. Delgado, I. Paterson, R. Britton, K. Poullennec, A. Meyer, A. Wright; 'Methods for the synthesis of dictyostatin and derivatives and analogues thereof, stereochemical characterization, novel dictyostatincompounds and uses thereof and synthetic intermediates' Publication date: July 28, 2005. Patent No. WO2005068451.2. R. Andersen, M. Roberge, R. Britton, D. De Silva; 'Antimitotic Eleuthosides' Publication date: December 30, 2004. Patent No.: US2004266700.1. R. Andersen, M. Roberge, S. Jasbinder, D. Leung, R. Berlinck, E. Piers, R. Britton; 'Granulatimide Derivatives for use in Cancer Treatment' Publication date: January 24, 2001. Patent No.: EP1070068 (also published as 'Granulatimide compounds and uses thereof' US6291447)

Books / Reviews

2. S. Chang, S. Halperin, J. Moore, R. Britton. "Chiral Auxiliaries in Drug Synthesis" In Stereoselective Synthesis of Drugs and Natural Products. V. Andrushko & N. Andrushko, Eds. Wiley, 2013

1. Britton, R. 'Natural Compounds as Drugs, Volumes I and II' Edited by Petersen, F.; Amstutz, R. 2009